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KMID : 0380620140460050641
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Korean Journal of Food Science and Technology
2014 Volume.46 No. 5 p.641 ~ p.647
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In vivo Study of the Renal Protective Effects of Capsosiphon fulvescens against Streptozotocin-induced Oxidative Stress
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Nam Mi-Hyun
Koo Yun-Chang
Hong Chung-Oui
Yang Sung-Yong
Kim Se-Wook
Jung Hye-Lim
Lee Hwa
Kim Ji-Yeon
Han Ah-Ram
Son Won-rak
Pyo Min-Cheol
Lee Kwang-Won
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Abstract
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In this study, we evaluated the effect of Capsosiphon fulvescens extract (CFE) and its active compound, pheophorbide A (PhA), on diabetic kidney failure. Diabetes mellitus (DM) was induced by a single intraperitoneal injection of streptozotocin (STZ; 40 mg/kg body weight (BW)). After a week, the rats were orally administered CFE (4 and 20 mg/ kg BW) or PhA (0.2 mg/kg BW) once a day for 9 weeks. After scarification, renal tissue samples were collected for biochemical and histochemical analyses. Our study showed that the treatment with CFE and PhA significantly decreased lipid peroxidation level and the activities of glutathione peroxidase and glutathione-S-transferase (p<0.05), but it increased glutathione level and the activities of glutathione reductase, superoxide dismutase, and catalase in the renal tissues (p<0.05). The CFE- and PhA-treated rats with DM showed improved histochemical appearance and decreased abnormal glycogen accumulation. Therefore, we suggest that PhA-containing CFE could exert renal protective effects against STZinduced oxidative stress.
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KEYWORD
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Capsosiphon fulvescens, streptozotocin, diabetic rats, oxidative stress, antioxidant enzyme, renal protective effects
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